流行病与卫生统计学专业英语

People living in economically disadvantaged circumstances experience higher risks of infections and death from arboviruses. However, more evidence is needed to better understand the socioeconomic factors influencing dengue mortality. We investigated if people of lower socioeconomic conditions in Brazil are more likely to die following dengue infection.

Linking nationwide socioeconomic data from the 100 Million Brazilian Cohort with dengue disease and death records registered in Brazil between 1 st January 2007 and 31 st December 2018, we used multivariable hierarchical analysis to investigate the socioeconomic determinants of dengue-specific and all-cause mortality within 15 days of dengue symptom onset. Among the 3,018,131 individuals from the 100 Million Brazilian Cohort diagnosed with dengue, 1810 died from dengue (Case Fatality Rate (CFR)=0.06%, 95%CI = 0.06-0.06%) and 3076 (CFR = 0.10%, 95%CI = 0.10-0.11%) died from any cause within 15 days of dengue symptom onset. People residing in the Northeast (OR=2.32; 95%CI = 1.74-3.10) and Midwest (OR=1.68; 95%CI = 1.25-2.27) regions, self-identifying as black race/ethnicity (OR=1.58; 95%CI = 1.31-1.90), having lower level of education (OR=2.35, 95%CI = 1.17-4.73), being retired/receiving pension (OR=2.24; 95%CI = 1.76-2.86), living in a household with rudimentary sewage (OR=1.19; 95%CI = 1.04-1.37) and having >2 inhabitants per room (OR=1.31; 95%CI = 1.11-1.55) had at higher odds of dengue-specific mortality. Similar characteristics were also associated with higher all-cause mortality after dengue infection, but also included residing in North region (OR=1.60; 95%CI = 1.24-2.06) and rural areas (OR=1.12; 95%CI = 1.01-1.24), self-identifying as Asian (OR=1.65; 95%CI = 1.07-2.54) and mixed race/brown (OR=1.20; 95%CI = 1.10-1.31) and living in households with poorer quality building and sanitary conditions.